maximum lifespan of a human

Last year (October 2016), a number of scientists pronounced that humans can not live longer than 115 years old.

This, despite the fact that a French woman, Jeanne Calment, died aged 122.

The problem arose because these scientists based their pronouncement on existing data, not factoring in the fact that we have never in the history of medicine applied ourselves to solving aging itself, but rather to solving the health issues that arise as side effects of aging.

This is similar in a way to stating that the highest point a person could ever touch on a wall is about 2.5 meters above ground, totally ignoring that we can invent stools or ladders.

Aging is only recently being recognised as a disease, and the fundamental causes of it are still being identified.

One reason we have an apparent limit on longevity is that genes have a “half-life” of sorts, where they can only divide a certain maximum number of times before they refuse to divide anymore. This limit is called the “Hayflick limit” after the person who noticed it.

The reason that genes won’t divide forever is that the ends of them, the telomeres, get shorter each time a division happens, and eventually they are so short that another division might cause a loss of functional code, so the cells notice this and refuse to divide anymore, going into senescence mode.

There are two treatments which can solve this issue.

Firstly, there is a treatment which has been demonstrated to lengthen the telomeres. If this treatment is repeated each ten-fifteen years, the telomeres should stay long indefinitely.

Second, you can kill the already-senescent cells by blocking the FOXO4 protein using a FOXO4-DRI (a FOXO4 peptide whose amino acid sequence has been reversed). This allows the senescent cells to die off, letting the body replace them with fresher cells.

And to help the DNA replicate more correctly, probably reducing the frequency that telomere treatment would be needed, you can increase the NAD+ in your cells by using NMN supplements.

People in the past never had access to those treatments, so it is understandable that there was an apparent limit to lifespan, but there really is no excuse – a scientist should never make an absolute claim like that which can so easily be shown to be false.

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Niacin dosage for high cholesterol

The recommended daily dosage of niacin is 16mg (males) or 14mg (females), with a maximum dosage of 35mg, beyond which you end up with a niacin flush. Niacin flushes are not dangerous, but they can be uncomfortable.

Niacin is a precursor for (it turns into) nicotinamide mononucleotide (NMN), which in turn is a precursor for nicotinamide adenine dinucleotide (NAD), which helps your DNA repair itself.

The nutritional need for niacin was first noted in 1937, 100 years after its first discovery, after a long chase for the cause and cure of Pellegra in the US.

Studies found that high-dosage niacin can reduce high cholesterol levels (hypercholesterolemia). The niacin dosage for high cholesterol is 1-6 grams of niacin daily, starting from a lower 100mg per day and increasing steadily. This is best done using a slow-release supplement, which will reduce the “hit” that the body receives, thus lowering the effect of the niacin flush.

High dosages of niacin cause liver damage, with symptoms of jaundice, itching, nausea, vomiting and fatigue. However, the damage is usually mild, and will stop as soon as the niacin overdosage is stopped.

Live Forever – the blog

This short article is an introduction to what I’m trying to achieve here, and how.

I started writing a book on how to live forever a few years ago, but never got much beyond the first few pages.

It’s becoming more and more probable that the first person to live to two hundred has already been born, so I wanted to create a book that would describe the current state of research, and ideas on how we can achieve full immortality (not just life extension)/

I have enough content in the book now that I can start putting together a website for it.

My idea is that by putting the entire content of the book online, I can use split-testing to try make it better, by carefully analysing what pages of the book lead to people moving onto the next page, etc.

With the book, I am trying to be as factual as possible about everything, with references for everything that might be contentious.

For the most part, the book’s content is general knowledge – don’t smoke, avoid obesity, exercise – but there is a lot of stuff that people don’t know about, and that sounds really crazy (for want of a better word!) at first hearing.

You’ve probably never heard of NAD+, FOXO4 peptides, or telomere lengthening, for example.

These are properly researched methods to keep your body’s cells young. You will have heard, for example, that red wine is good for you because of something called Resveretrol. Well, David Sinclair, the scientist behind that research went on to research something else called NAD. It turns out there is very solid evidence that this extends life in mice, and there are human trials that suggest the same thing. Of course, we live longer than mice, so we won’t be certain of this for a long time, but the evidence is strong enough that Sinclair and his team take the NMN supplement themselves (which increases NAD in your cells).

On the crazy side, I’ve also written about Quantum Immortality – the idea that you cannot die, because there are infinite universes and there will always be at least one in which you (or an exact clone, right down to the memories) will wake up tomorrow – which is not really as mad as it sounds. Especially if you compare it with some ideas that various religions state as fact.