Rewriting the Senescent Cells chapter

Last week, I rewrote the How to Live Forever book’s introduction chapter so I had two different copies. This lets me display one or the other randomly to each visitor to the website, letting me figure out through visitor interactions which chapter catches the attention more and is easier to read.

This week, after resetting the Introduction’s stats, I checked and the next-most popular page was “killing senescent cells with the FOXO4 DRI peptide”, so I’ll rewrite that this week.

The first thing I did was to rename it “Senescent Cells”, since the focus should really be on the problem, senescence, instead of the solution, senolytics. When I first wrote the chapter, the only senolytic that people were talking about was FOXO4-DRI, but since then, others such as UBX0101 and Navitoclax have been mentioned as well. There are about 25 or so senolytics in trial in various clinics. So, I renamed the chapter to be more about what senolytics are for, and not to be about a specific one.

When I rewrote the Introduction chapter, I basically just read the original, then paraphrased it. This was okay to do because the introduction is just a general overview – it doesn’t have a lot of details in it.

When rewriting every other chapter, though, more care needs to be taken. Every sentence has something to say, so I need to make sure that the rewrite includes everything that the original had.

The first rewrite will be a rough draft paraphrase, just like last week’s rewrite. But then I’ll go through carefully and make sure that I included everything written in the original, and finally will try to find new information to talk about, since the focus is no longer on the DRI peptide, but is now on senescent cells themselves.

This should be easy enough, because there are new human trials and new drugs that have come to light since I wrote the original.

I had another idea as well, which is to illustrate the concepts in cartoon form. This will let me explain visually some of the ideas that are hard to explain with words. Of course, I can’t draw, so this may take some redraws to get it right.

Because senolytics such as the FOXO4-DRI peptides are not currently available even to clinics, I will also include some information such as where to buy senolytics.

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