I was looking for updates on human trials for NMN (nicotinamide mononucleotide) when I noticed this.
NMN is one of a group of chemicals which is being looked at for their anti-senescence or senolytic properties. In NMN’s case, it helps to increase NAD+ in mitochondria, making it easier for older cells to generate energy to replicate correctly.
It turns out that NMN can also work with the SIRT3 protein to increase the presence of frataxin, which is a protein used in mitochondria and important for heart function.
People that have the disease Friedrich’s Ataxia have a mutation in their DNA which leads to reduced expression of frataxin in their mitochondria. Later in life, this leads to a list of issues, such as scoliosis, diabetes, heart disorders.
In mouse tests, it was shown that mice that had their frataxin-producing genes completely turned off were restored to good heart health after being treated with NMN.